Cell proliferation on fibrin: modulation by fibrinopeptide cleavage
نویسندگان
چکیده
منابع مشابه
Cell proliferation on fibrin: modulation by fibrinopeptide cleavage.
Fibrin forms the cohesive network of hemostatic plugs and thrombi, and it also provides the temporary matrix for initial support of healing and revascularization. Because cell proliferation is needed for revascularization after vessel injury, we have characterized structural requirements of fibrin needed to support cell proliferation on fibrin in vitro. Proliferation of cultured human endotheli...
متن کاملEndothelial cell spreading on fibrin requires fibrinopeptide B cleavage and amino acid residues 15-42 of the beta chain.
Adhesion and spreading of cultured human umbilical vein endothelial cells on fibrin surfaces of varying structure were characterized to understand better the interactions occurring between endothelium and fibrin at sites of vascular injury. Fibrin prepared with reptilase, which cleaves only fibrinopeptide A from fibrinogen, and fibrin prepared with thrombin, which cleaves both fibrinopeptide A ...
متن کاملRadioimmunoassay of human fibrinopeptide B and kinetics of fibrinopeptide cleavage by different enzymes.
Thrombin converts fibrinogen to fibrin monomer by cleaving fibrinopeptides A and B (FPA and FPB) from the amino terminal ends of the A (alpha) and B (beta) chains. A radioimmunoassay capable of measuring the A peptide in human blood as an index of thrombin action in vivo has been described previously. This paper describes the development of a radioimmunoassay for FPB and the use of both assays ...
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Release of fibrinopeptide B from fibrinogen by copperhead venom procoagulant enzyme results in a form of fibrin ($-f,brin) with weaker self-aggregation characteristics than the normal product (a/9-fibrin) produced by release of fibrinopeptides A (FPA) and B (FPB) by thrombin. We investigated the ultrastructure of these two types of fibrin as well as that of $-fibrin prepared from fibrinogen Met...
متن کاملFibrin Stimulates Keratinocyte Proliferation
Received February 9, 2005; revision accepted for publication June 21, 2005. Correspondence: Misa Yamamoto, MT (Medical Technologist), CT (Cytologist), Faculty of Health Sciences, Yamaguchi University School of Medicine, MinamiKogushi 1-1-1, Ube, Yamaguchi, 755-8554, Japan. e-mail: [email protected] Fibrin Stimulates the Proliferation of Human Keratinocytes through the Autocrine Mechani...
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ژورنال
عنوان ژورنال: Blood
سال: 1995
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v86.5.1802.bloodjournal8651802